Automated substance testing for lab-on-chip devices

Automated substance testing for lab-on-chip devices

Background A smartphone-sized multi-organ-chip has been developed by TissUse. This platform consists of a microcirculation system which contains several fully endothelial-cellcoated microchannels in which organ equivalents are embedded. Briefly, Human 3D organ equivalents such as liver and skin could be maintained functional over 28 days and treated with chemical entities in this microcirculati...

Chitosan: an integrative biomaterial for lab-on-a-chip devices.

Chitosan is a naturally derived polymer with applications in a variety of industrial and biomedical fields. Recently, it has emerged as a promising material for biological functionalization of microelectromechanical systems (bioMEMS). Due to its unique chemical properties and film forming ability, chitosan serves as a matrix for the assembly of biomolecules, cells, nanoparticles, and other subs...

Biosample Preparation by Lab-on-a-Chip Devices

The main objective of this chapter is to review the on-chip molecular sample preparation methods. For an on-chip sample preparation for large biological objects, such as cells and particles, prior to the molecular sample preparation, there are several methods available such as dielectrophoresis, hydrophoretic filtration, and separation via magnetic forces, acoustic forces, and optical forces. T...

Improving fluorescence detection in lab on chip devices.

Lab-on-chip systems for integrated bioanalyses

Biomolecular detection systems based on microfluidics are often called lab-on-chip systems. To fully benefit from the miniaturization resulting from microfluidics, one aims to develop 'from sample-to-answer' analytical systems, in which the input is a raw or minimally processed biological, food/feed or environmental sample and the output is a quantitative or qualitative assessment of one or mor...